A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction

Anna Helgadóttir(Reykjavík University), Guðmar Þorleifsson(Reykjavík University), Andrei Manolescu(Reykjavík University), Sólveig Grétarsdóttir(Reykjavík University), Thórarinn Blöndal(Reykjavík University), Áslaug Jónasdóttir(Reykjavík University), Aðalbjörg Jónasdóttir(Reykjavík University), Ásgeir Sigurðsson(Reykjavík University), Adam Baker(Reykjavík University), Arnar Pálsson(Reykjavík University), Gísli Másson(Reykjavík University), Daníel F. Guðbjartsson(Reykjavík University), Kristinn P. Magnússon(Reykjavík University), Karl Andersen(Reykjavík University), Allan I. Levey(Reykjavík University), Valgerdur M. Backman(Reykjavík University), Sigurborg Matthiasdottir(Reykjavík University), Þorbjörg Jónsdóttir(Reykjavík University), Stefan Palsson(Reykjavík University), H Einarsdottir(Reykjavík University), Steinunn Gunnarsdottir(Reykjavík University), Arnaldur Gylfason(Reykjavík University), Viola Vaccarino(Reykjavík University), W. Craig Hooper(Reykjavík University), Muredach P. Reilly(Reykjavík University), Christopher B. Granger(Reykjavík University), Harland Austin(Reykjavík University), Daniel J. Rader(Reykjavík University), Svati H. Shah(Reykjavík University), Arshed A. Quyyumi(Reykjavík University), Jeffrey R. Gulcher(Reykjavík University), Guðmundur Þorgeirsson(Reykjavík University), Unnur Þorsteinsdóttir(Reykjavík University), Augustine Kong(Reykjavík University), Kāri Stefánsson(Reykjavík University)
Science
May 3, 2007
10.1126/science.1142842
Cited by 1,595

Abstract

The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.

Related Papers

No related papers found

Powered by citation graph analysis