G Protein-coupled Receptors
Tae H. Ji(University of Wyoming), Mathis Grossmann(Walter and Eliza Hall Institute of Medical Research), Inhae Ji(Walter and Eliza Hall Institute of Medical Research)
Cited by 1,291Open Access
Abstract
Nearly 2000 G protein-coupled receptors (GPCRs)1 have been reported since bovine opsin was cloned in 1983 (1) and the β-adrenergic receptor in 1986 (2). They are classified into over 100 subfamilies according to the sequence homology, ligand structure, and receptor function. A substantial degree of amino acid homology is found among members of a particular subfamily, but comparisons between subfamilies show significantly less or no similarity.
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