Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.

Kenneth A. Thomas(Merck & Co., Inc., Rahway, NJ, USA (United States)), M Rios-Candelore(Merck & Co., Inc., Rahway, NJ, USA (United States)), Guillermo Giménez‐Gallego(Merck & Co., Inc., Rahway, NJ, USA (United States)), Jerry DiSalvo(Merck & Co., Inc., Rahway, NJ, USA (United States)), Carl D. Bennett, J A Rodkey, S L Fitzpatrick
Proceedings of the National Academy of Sciences
October 1, 1985
Cited by 295Open Access
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Abstract

Pure bovine brain-derived acidic fibroblast growth factor is a very potent mitogen for vascular endothelial cells in culture and, in the presence of heparin, induces blood vessel growth in vivo. Partial amino acid sequence determinations confirm that this mitogen is a unique protein having amino acid sequence homology with human interleukin 1.


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