Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

Ramin Nazarian; Hubing Shi; Qi Wang; Xiangju Kong; Richard C. Koya; Hane Lee; Zugen Chen; Mi‐Kyung Lee; Narsis Attar; Hooman Sazegar; Thinle Chodon; Stanley F. Nelson; Grant A. McArthur; Jeffrey A. Sosman; Antoni Ribas; Roger S. Lo

doi:10.1038/nature09626

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

Ramin Nazarian(UCLA Jonsson Comprehensive Cancer Center), Hubing Shi(UCLA Jonsson Comprehensive Cancer Center), Qi Wang(UCLA Jonsson Comprehensive Cancer Center), Xiangju Kong(UCLA Jonsson Comprehensive Cancer Center), Richard C. Koya(UCLA Jonsson Comprehensive Cancer Center), Hane Lee(University of California, Los Angeles), Zugen Chen(University of California, Los Angeles), Mi‐Kyung Lee(UCLA Jonsson Comprehensive Cancer Center), Narsis Attar(University of California, Los Angeles), Hooman Sazegar(UCLA Jonsson Comprehensive Cancer Center), Thinle Chodon(University of California, Los Angeles), Stanley F. Nelson(University of California, Los Angeles), Grant A. McArthur(Peter MacCallum Cancer Centre), Jeffrey A. Sosman(Vanderbilt-Ingram Cancer Center), Antoni Ribas(UCLA Jonsson Comprehensive Cancer Center), Roger S. Lo(UCLA Jonsson Comprehensive Cancer Center)

Nature

November 24, 2010

10.1038/nature09626

Cited by 2,154

Abstract

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