Inhibition of association vs. dissociation of high-avidity DNA/Anti-DNA Conplexes: Possible involvement of secondary hydrogen bonds
Carel J. van Oss(University at Buffalo, State University of New York), K. J. T. Smeenk(Dutch Blood Transfusion Society), L. A. Aarden(Dutch Blood Transfusion Society)
Cited by 29
Abstract
Recent results on the conditions of ionic strength needed to prevent the association of dsDNA with high avidity human anti-dsDNA, were compared with the insufficiency of even the highest practicable ionic strengths to effect the dissociation of such antigen-antibody complexes, once formed (1). Further analysis of these results make us conclude that such high avidity dsDNA-anti-dsDNA complexes, which in the initial stages of their formation are mainly of the Coulombic variety, subsequently evolve, at least in part, into hydrogen bonds.
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