Clinical toxicology study of an herbal medicinal extract of <i>Paullinia cupana, Trichilia catigua, Ptychopetalum olacoides</i> and <i>Zingiber officinale</i> (Catuama<sup>®</sup>) in healthy volunteers
Celso Henrique de Oliveira(Universidade Estadual de Campinas (UNICAMP)), Maria Elizabete Amaral de Moraes(Universidade Federal do Ceará), Manoel Odorico de Moraes(Universidade Federal do Ceará), Fernando Antônio Frota Bezerra(Universidade Federal do Ceará), Eduardo Abib, Gilberto De Nucci
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Abstract
In Brazil, a herbal medicinal extract named Catuama containing a mixture of Paullinia cupana (guarana; Sapindaceae), Trichilia catigua (catuaba; Meliaceae), Ptychopetalum olacoides (muirapuama; Olacaceae) and Zingiber officinale (ginger; Zingiberaceae) is used as a body stimulant, energetic, tonic and aphrodisiac. The present study investigated the chronic administration of 25 mL Catuama twice a day during 28 days for any toxic effect on healthy human volunteers of both sexes. No severe adverse reactions or haematological and biochemical changes were reported.
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