BioMEMS Platform for Electromechanical Stimulation of Cell Culture
Jennifer T. Blundo(Stanford University), Gretchen Chua(Stanford University), Oscar J. Abilez(Stanford University), Yong‐Lae Park(Stanford University), Ali J. Rastegar(Stanford University), Feng Cao(Stanford University), Chris Zarins(Stanford University), Joseph C. Wu(Stanford University), Beth L. Pruitt(Stanford University)
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Abstract
A BioMEMS platform was designed and fabricated to enable electromechanical stimulation of cell cultures. The device consists of a stretchable microelectrode array embedded in a biocompatible elastomeric polymer, which is deformed by vacuum over a glass baseplate. The entire device is optically transparent and ∼1mm thick. Four cell culture wells apply electrical and/or mechanical stimulation in the range of 1–10 V/cm and 0–10% equibiaxial strain. Studies of electromechanical stimulation of cardiac myocyte precursors on this platform are proposed to elucidate mechanisms of differentiation.
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