Detection of Cell-Affecting Agents with a Silicon Biosensor
J. Wallace Parce(Molecular Devices (United Kingdom)), John C. Owicki(Molecular Devices (United Kingdom)), K M Kercso(Molecular Devices (United Kingdom)), George B. Sigal(Molecular Devices (United Kingdom)), H G Wada(Molecular Devices (United Kingdom)), Victoria C. Muir(Molecular Devices (United Kingdom)), Luc Bousse(Molecular Devices (United Kingdom)), Kevin L. Ross(Stanford Medicine), Branimir I. Šikić(Stanford Medicine), Harden M. McConnell(Stanford University)
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Abstract
Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety of chemical and physical stimuli. A biosensor has been constructed in which living cells are confined to a flow chamber in which a potentiometric sensor continually measures the rate of production of acidic metabolites. Exploratory studies demonstrate several applications of the device in basic science and technology.
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