Targeting the cancer kinome through polypharmacology

Zachary A. Knight(Howard Hughes Medical Institute), Kevan M. Shokat(Howard Hughes Medical Institute), Henry J. Lin(The Lundquist Institute)

Nature reviews. Cancer

January 22, 2010

10.1038/nrc2787

Cited by 683

Related Papers

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

|Nature|2013|2.5k

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

|Nature|2010|1.8k

IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

|Science|2007|1.4k

The translational landscape of mTOR signalling steers cancer initiation and metastasis

|Nature|2012|1.4k

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

|Cell|2006|1.2k