Stereochemical Control of the Passerini Reaction

Peter R. Andreana(Harvard University), Chang C. Liu(Howard Hughes Medical Institute), Stuart L. Schreiber(Howard Hughes Medical Institute)
Organic Letters
October 12, 2004
Cited by 172

Abstract

A catalytic asymmetric Passerini reaction using tridentate indan (pybox) Cu(II) Lewis acid complex 4 with substrates capable of bidentate coordination has been achieved. The reaction occurs via ligand-accelerated catalysis.


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