Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

June M. Chan(Northwestern University), Meir J. Stampfer(Northwestern University), Edward L. Giovannucci(Northwestern University), Peter H. Gann(Northwestern University), Jing Ma(Northwestern University), Peter Wilkinson(Northwestern University), Charles H. Hennekens(Northwestern University), Michaël Pollak(Northwestern University)
Science
January 23, 1998
10.1126/science.279.5350.563
Cited by 2,010

Abstract

Insulin-like growth factor-I (IGF-I) is a mitogen for prostate epithelial cells. To investigate associations between plasma IGF levels and prostate cancer risk, a nested case-control study within the Physicians' Health Study was conducted on prospectively collected plasma from 152 cases and 152 controls. A strong positive association was observed between IGF-I levels and prostate cancer risk. Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. This association was independent of baseline prostate-specific antigen levels. Identification of plasma IGF-I as a predictor of prostate cancer risk may have implications for risk reduction and treatment.

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