Sickle-Cell Anemia and Other Hemoglobinopathies
Michael D. Garrick(University at Buffalo, State University of New York), Philip P. Dembure(University at Buffalo, State University of New York), Robert Guthrie(University at Buffalo, State University of New York)
Cited by 141
Abstract
Abstract Since blood spots on filter paper are routinely collected in many areas for phenylketonuria testing of newborn infants, we developed several methods for detecting sickle-cell disease and other hemoglobinopathies using this type of specimen. Simple, inexpensive modifications of cellulose acetate electrophoresis plus citrate-agar and globin-chain electrophoresis are employed, permitting one technician to screen as many as 500 specimens per day at a material cost of $0.03 per specimen. (N Engl J Med 288:1265–1268, 1973)
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