Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Anna Velcich(Albert Einstein College of Medicine), Wancai Yang(Albert Einstein College of Medicine), Joerg Heyer(Yeshiva University), Alessandra Fragale(Albert Einstein College of Medicine), Courtney Nicholas(Albert Einstein College of Medicine), Stephanie Viani(Albert Einstein College of Medicine), Raju Kucherlapati(Brigham and Women's Hospital), Martin Lipkin(Yeshiva University), Kan Yang(Yeshiva University), Leonard H. Augenlicht(Albert Einstein College of Medicine)
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Abstract
The gastrointestinal tract is lined by a layer of mucus comprised of highly glycosylated proteins called mucins. To evaluate the importance of mucin in intestinal carcinogenesis, we constructed mice genetically deficient in Muc2, the most abundant secreted gastrointestinal mucin. Muc2-/- mice displayed aberrant intestinal crypt morphology and altered cell maturation and migration. Most notably, the mice frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors. Thus, Muc2 is involved in the suppression of colorectal cancer.