N-formylmethionyl peptides as chemoattractants for leucocytes.
E Schiffmann, Barbara Corcoran, Sharon M. Wahl(National Institute of Dental and Craniofacial Research)
Cited by 888
Abstract
Leucocytes such as neutrophils are attracted by N-formylmethionine, but not by methionine. Di- and tripeptides containing formylmethionine are strong attractants for both neutrophils and macrophages, whereas the corresponding nonacylated compounds are not chemotactic. The formylated peptides may be related to an incompletely characterized chemotactic material normally produced by bacteria which attract the same animal cells.