Multistep Control of Pituitary Organogenesis
Hui Z. Sheng(Shimane University), Kenji Moriyama(Shimane University), Tsuyoshi Yamashita(Shimane University), Hung Li(Shimane University), S. Steven Potter(Shimane University), Kathleen Mahon(Shimane University), Heiner Westphal(Shimane University)
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Abstract
Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps-first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4 have redundant control over formation of the definitive pouch. Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.
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