Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells
Sara Lombardi(King's College London), Gabriella Honeth(King's College London), Christophe Ginestier(Inserm), Ireneusz Shinomiya(King's College London), Rebecca Marlow(King's College London), Bharath Buchupalli(King's College London), Patrycja Gazińska(King's College London), John P. Brown(King's College London), Steven Catchpole(King's College London), Suling Liu(University of Michigan), Ariel L. Barkan(University of Michigan), Max S. Wicha(University of Michigan), Anand Purushotham(King's College London), Joy Burchell(King's College London), Sarah E. Pinder(King's College London), Gabriela Dontu(King's College London)
Cited by 55Open Access
Abstract
Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.
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