Acute intoxication with sodium valproate
David Chadwick(Royal Victoria Infirmary), W. J. K. Cumming(Royal Victoria Infirmary), I. Livingstone(Royal Victoria Infirmary), N.E.F. Cartlidge(Royal Victoria Infirmary)
Cited by 72
Abstract
Two epileptic patients developed an acute toxic encephalopathy consisting of altered behavior, deteriorating seizure control, and confusion while taking sodium valproate alone. Serum valproate levels were greater than 100 microgram/ml in both. Toxic symptoms resolved when the dose of valproate was reduced, with a consequent fall in serum concentration of the drug.
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