G Protein-Coupled Receptors in <i>Anopheles gambiae</i>
Catherine A. Hill(University of Notre Dame), A. Nicole Fox(Vanderbilt University), R. Jason Pitts(Vanderbilt University), Lauren B. Kent(University of Illinois Urbana-Champaign), Perciliz L. Tan(University of Notre Dame), Mathew A. Chrystal(University of Notre Dame), Anibal Cravchik(Westat (United States)), Frank H. Collins(University of Notre Dame), Hugh M. Robertson(University of Illinois Urbana-Champaign), Laurence J. Zwiebel(Vanderbilt University)
Cited by 681
Abstract
We used bioinformatic approaches to identify a total of 276 G protein-coupled receptors (GPCRs) from the Anopheles gambiae genome. These include GPCRs that are likely to play roles in pathways affecting almost every aspect of the mosquito's life cycle. Seventy-nine candidate odorant receptors were characterized for tissue expression and, along with 76 putative gustatory receptors, for their molecular evolution relative to Drosophila melanogaster. Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation.
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