Requirement of <i>bic/microRNA-155</i> for Normal Immune Function

Antony Rodriguez(Babraham Institute), Elena Vigorito(Babraham Institute), Simon Clare(Babraham Institute), Madhuri Warren(Babraham Institute), Philippe Couttet(Babraham Institute), Dalya R. Soond(Babraham Institute), Stijn van Dongen(Babraham Institute), Russell Grocock(Babraham Institute), Partha Pratim Das(Babraham Institute), Eric A. Miska(Babraham Institute), David Vetrie(Babraham Institute), Klaus Okkenhaug(Babraham Institute), Anton J. Enright(Babraham Institute), Gordon Dougan(Babraham Institute), Martin Turner(Babraham Institute), Allan Bradley(Babraham Institute)
Science
April 26, 2007
10.1126/science.1139253
Cited by 1,843Open Access
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Abstract

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155-deficient CD4+ T cells identified a wide spectrum of microRNA-155-regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.

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