Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle; Beat Nyfeler; Jane Nagel; R.A. Elling; Shanming Liu; Ellen Triantafellow; Suchithra Menon; Zuncai Wang; Ayako Honda; Gwynn Pardee; John Cantwell; Catherine A. Luu; Iván Cornella‐Taracido; Edmund Harrington; Peter Fekkes; Hong Lei; Qing Fang; Mary Ellen Digan; Debra Burdick; Andrew F. Powers; Stephen B. Helliwell; Simon d‘Aquin; Julie Bastien; Henry Wang; Dmitri Wiederschain; Jenny Kuerth; Philip J. Bergman; David J. Schwalb; Jason R. Thomas; Savuth Ugwonali; Fred Harbinski; John A. Tallarico; Christopher J. Wilson; Vic E. Myer; Jeffery A. Porter; Dirksen E. Bussiere; Peter M. Finan; Mark Labow; Xiaohong Mao; Lawrence G. Hamann; Brendan D. Manning; Reginald Valdez; Thomas Nicholson; Markus Schirle; Mark Knapp; Erin P. Keaney; Leon O. Murphy

doi:10.1038/ncb3053

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle(Novartis (Switzerland)), Beat Nyfeler(Novartis (Switzerland)), Jane Nagel(Novartis (Switzerland)), R.A. Elling(Novartis (Switzerland)), Shanming Liu(Novartis (Switzerland)), Ellen Triantafellow(Novartis (Switzerland)), Suchithra Menon(Novartis (Switzerland)), Zuncai Wang(Novartis (Switzerland)), Ayako Honda(Novartis (Switzerland)), Gwynn Pardee(Novartis (Switzerland)), John Cantwell(Novartis (Switzerland)), Catherine A. Luu(Novartis (Switzerland)), Iván Cornella‐Taracido(Novartis (Switzerland)), Edmund Harrington(Novartis (Switzerland)), Peter Fekkes(Novartis (Switzerland)), Hong Lei(Novartis (Switzerland)), Qing Fang(Novartis (Switzerland)), Mary Ellen Digan(Novartis (Switzerland)), Debra Burdick(Novartis (Switzerland)), Andrew F. Powers(Novartis (Switzerland)), Stephen B. Helliwell(Novartis (Switzerland)), Simon d‘Aquin(Novartis (Switzerland)), Julie Bastien(Novartis (Switzerland)), Henry Wang(Novartis (Switzerland)), Dmitri Wiederschain(Novartis (Switzerland)), Jenny Kuerth(Novartis (Switzerland)), Philip J. Bergman(Novartis (Switzerland)), David J. Schwalb(Novartis (Switzerland)), Jason R. Thomas(Novartis (Switzerland)), Savuth Ugwonali(Novartis (Switzerland)), Fred Harbinski(Novartis (Switzerland)), John A. Tallarico(Novartis (Switzerland)), Christopher J. Wilson(Novartis (Switzerland)), Vic E. Myer(Novartis (Switzerland)), Jeffery A. Porter(Novartis (Switzerland)), Dirksen E. Bussiere(Novartis (Switzerland)), Peter M. Finan(Novartis (Switzerland)), Mark Labow(Novartis (Switzerland)), Xiaohong Mao(Novartis (Switzerland)), Lawrence G. Hamann(Novartis (Switzerland)), Brendan D. Manning(Harvard University), Reginald Valdez(Novartis (Switzerland)), Thomas Nicholson(Novartis (Switzerland)), Markus Schirle(Novartis (Switzerland)), Mark Knapp(Novartis (Switzerland)), Erin P. Keaney(Novartis (Switzerland)), Leon O. Murphy(Novartis (Switzerland))

Nature Cell Biology

October 19, 2014

10.1038/ncb3053

Cited by 738

Abstract

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