Redesigning Nature's Poisons to Create Anti-Tumor Reagents
Ellen S. Vitetta(The University of Texas Southwestern Medical Center), R J Fulton(The University of Texas Southwestern Medical Center), Richard May(The University of Texas Southwestern Medical Center), Mark Till(The University of Texas Southwestern Medical Center), Jonathan W. Uhr(The University of Texas Southwestern Medical Center)
Cited by 327
Abstract
Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.
Related Papers
No related papers found
Powered by citation graph analysis