Lipid droplets: A dynamic organelle moves into focus

Mathias Beller(Max Planck Institute for Biophysical Chemistry), Katharina Thiel(Max Planck Institute for Biophysical Chemistry), Peter Thul(Max Planck Institute for Biophysical Chemistry), Herbert Jäckle(Max Planck Institute for Biophysical Chemistry)
FEBS Letters
March 18, 2010
10.1016/j.febslet.2010.03.022
Cited by 264Open Access
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Abstract

Lipid droplets (LDs) were perceived as static storage deposits, which passively participate in the energy homeostasis of both cells and entire organisms. However, this view has changed recently after the realization of a complex and highly dynamic LD proteome. The proteome contains key components of the fat mobilization system and proteins that suggest LD interactions with a variety of cell organelles, including the endoplasmic reticulum, mitochondria and peroxisomes. The study of LD cell biology, including cross-talk with other organelles, the trafficking of LDs in the cell and regulatory events involving the LD coat proteins is now on the verge of leaving its infancy and unfolds that LDs are highly dynamic cellular organelles.

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