Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search
Jeffrey R. Smith(University of Michigan), Diha Freije(Walsh University), John D. Carpten(National Human Genome Research Institute), Henrik Grönberg(Walsh University), Jianfeng Xu(Johns Hopkins University), Sarah D. Isaacs(Walsh University), Michael Brownstein(National Institute of Mental Health), G. Steven Bova(Walsh University), Hong Guo-Parke(Walsh University), Piroska Bujnovszky(Walsh University), Deborah Nusskern(Walsh University), J.‐E. Damber(National Human Genome Research Institute), Anders Bergh(National Human Genome Research Institute), M. Emanuelsson(Umeå University), Olli Kallioniemi(National Human Genome Research Institute), Jennifer Walker‐Daniels(National Human Genome Research Institute), Joan E. Bailey‐Wilson(National Human Genome Research Institute), Terri H. Beaty(Johns Hopkins University), Deborah A. Meyers(Johns Hopkins University), Patrick C. Walsh(Walsh University), Francis S. Collins(National Human Genome Research Institute), Jeffrey M. Trent(National Human Genome Research Institute), William B. Isaacs(Walsh University)
Cited by 830
Abstract
Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.
Related Papers
Mendelian inheritance of familial prostate cancer.
B S Carter, Terri H. Beaty, Gary D. Steinberg et al.|Proceedings of the National Academy of Sciences|1992|786