The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function
J M McCune(Stanford University), Reiko Namikawa(Stanford University), Hideto Kaneshima(Stanford University), L D Shultz(Jackson Laboratory), M Lieberman(Stanford University), I L Weissman(Stanford University)
Cited by 1,377
Abstract
The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.