In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Luigi Naldini(Torrey Pines Institute For Molecular Studies), Ulrike Blömer(Torrey Pines Institute For Molecular Studies), Philippe Gallay(Torrey Pines Institute For Molecular Studies), Daniel Ory(Whitehead Institute for Biomedical Research), Richard C. Mulligan(Whitehead Institute for Biomedical Research), Fred H. Gage(Torrey Pines Institute For Molecular Studies), Inder M. Verma(Torrey Pines Institute For Molecular Studies), Didier Trono(Torrey Pines Institute For Molecular Studies)
Cited by 4,901
Abstract
A retroviral vector system based on the human immunodeficiency virus (HIV) was developed that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous sequences into HeLa cells and rat fibroblasts blocked in the cell cycle, as well as into human primary macrophages. Additionally, the HIV vector could mediate stable in vivo gene transfer into terminally differentiated neurons. The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy.
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