Assignment of the human UDP glucuronosyltransferase gene (UGT1A1) to chromosome region 2q37
Hazard Es(McGill University), A. Bout, J. Liu(McGill University), L. Anderson(Kingston General Hospital), Alessandra M.V. Duncan(Kingston General Hospital), Piter J. Bosma(Amsterdam UMC Location University of Amsterdam), R. Oude Elferink(Amsterdam UMC Location University of Amsterdam), Plm Jansen(Amsterdam UMC Location University of Amsterdam), Jayanta Roy Chowdhury(Albert Einstein College of Medicine), Erwin Schurr(McGill University)
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Abstract
UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.
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