Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease

Eliezer Masliah; Margaret Mallory; Michael Alford; Richard DeTeresa; Lawrence A. Hansen; Daniel W. McKeel; John C. Morris

doi:10.1212/wnl.56.1.127

Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease

Eliezer Masliah(University of California System), Margaret Mallory(University of California System), Michael Alford(University of California System), Richard DeTeresa(University of California System), Lawrence A. Hansen(University of California System), Daniel W. McKeel(University of California System), John C. Morris(University of California System)

Neurology

January 9, 2001

10.1212/wnl.56.1.127

Cited by 749Open Access

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Abstract

The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.

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