Correlates of pregnancy oestrogen, progesterone and sex hormone-binding globulin in the USA and China

Joanne Wuu(University of Massachusetts Chan Medical School), Susan Hellerstein(Beth Israel Deaconess Medical Center), Loren Lipworth(Vanderbilt University Medical Center), Leif Wide(Uppsala University Hospital), Biao Xu(Shanghai Medical College of Fudan University), G-P Yu(Shanghai Medical College of Fudan University), Hannah Kuper(Harvard University), P. Lagiou(Harvard University), Susan E. Hankinson(Brigham and Women's Hospital), Anders Ekbom(Harvard University), Kjell Carlström(Karolinska Institutet), D Trichopoulos(Harvard University), H-O Adami(Harvard University), C-C Hsieh(Harvard University)
European Journal of Cancer Prevention
June 1, 2002
10.1097/00008469-200206000-00012
Cited by 74

Abstract

The objective of this study is to examine perinatal correlates of oestradiol (E2), oestriol (E3), progesterone and sex hormone-binding globulin (SHBG) among pregnant women in the USA and China. Three hundred and four Caucasian women in Boston and 335 Chinese women in Shanghai were studied. Levels of E2, E3, progesterone and SHBG were measured in maternal blood at weeks 16 and 27 of gestation, and correlated with maternal, gestational and perinatal characteristics. Height, weight and body mass index (BMI) before pregnancy is inversely associated with E2 and SHBG, whereas E3 is inversely associated with height and progesterone is inversely associated with weight and BMI. A previous live birth is associated with lower E2 and SHBG in the index pregnancy. Total gestation duration is inversely associated with E2, E3 and progesterone, whereas weight gain during pregnancy is inversely associated with progesterone and SHBG. In the US, pregnancies with female fetuses are characterized by significantly reduced progesterone. Pregnancy hormones are associated with several maternal, gestational and neonatal characteristics.

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