Homozygous Hb J Tongariki: Evidence for Only One Alpha Chain Structural Locus in Melanesians
Ruth K. Abramson(University of Michigan), Donald L. Rucknagel(University of Michigan), Donald C. Shreffler(University of Michigan), Jan J. Saave(Port Moresby General Hospital)
Cited by 87
Abstract
A high frequency of Hb J Tongariki (alpha 115 Ala --> Asp) was found in a Kilenge village in New Britain. Heterozygotes had 45 to 50 percent of the Hb J component (determined by cellulose acetate electrophoresis). Two homozygotes for Hb J had no Hb A, suggesting that in this family only one Hbalpha structural locus is present.
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