Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies
Guillermo Giménez‐Gallego(Consejo Superior de Investigaciones Científicas), J A Rodkey(Merck & Co., Inc., Rahway, NJ, USA (United States)), Carl D. Bennett(Merck & Co., Inc., Rahway, NJ, USA (United States)), M Rios-Candelore(Merck & Co., Inc., Rahway, NJ, USA (United States)), Jerry DiSalvo(Merck & Co., Inc., Rahway, NJ, USA (United States)), Kenneth A. Thomas(Merck & Co., Inc., Rahway, NJ, USA (United States))
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Abstract
Bovine brain-derived acidic fibroblast growth factor (aFGF) is a protein mitogen originally identified in partially purified preparations of whole brain. The protein was purified to homogeneity and shown to be a potent vascular endothelial cell mitogen in culture and angiogenic substance in vivo. The homology of aFGF to human interleukin-1 beta was inferred from partial sequence data. The complete amino acid sequence of aFGF has now been determined and observed to be similar to both basic FGF and interleukin-1's. A neuropeptide-like sequence, flanked by basic dipeptides, was observed within the aFGF sequence.
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