Interleukin 6 is involved in interleukin 1‐induced activities

Maarten Helle(Dutch Blood Transfusion Society), Just P. J. Brakenhoff(Dutch Blood Transfusion Society), Els R. de Groot(Dutch Blood Transfusion Society), Lucien A. Aarden(Dutch Blood Transfusion Society)
European Journal of Immunology
June 1, 1988
10.1002/eji.1830180619
Cited by 412

Abstract

Human monocytes produce a number of soluble mediators involved in regulation of inflammation and lymphocyte growth and differentiation such as interleukin 1 (IL 1) and tumor necrosis factor. Recently, the cDNA of another monocyte-derived factor, interleukin 6 (IL 6), was cloned. Herein we show that purified E. coli-derived recombinant IL 6 (rIL 6) is as active as IL 1 in the thymocyte assay. In addition, IL 1 and IL 6 synergize strongly in stimulating thymocyte proliferation. Another property shared by IL 1 and IL 6 is their pyrogenicity. Human rIL 6 induces a monophasic fever after i.v. injection into rabbits. Together with the observation that IL 1 induces IL 6 in a variety of cells including thymocytes, our data suggest that IL 6 is involved in many of the pleiotropic effects of IL 1.

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