AN INVESTIGATION OF POLYMORPHISM IN THE INTERLEUKIN‐10 GENE PROMOTER
David M. Turner(University of Manchester), Denise Williams(University of Manchester), David Sankaran(University of Manchester), Mark Lazarus(University of Manchester), P. J. Sinnott(University of Manchester), Ian V. Hutchinson(University of Manchester)
Cited by 1,729
Abstract
Interleukin-10 (IL-10) has been described as an anti-inflammatory cytokine and B-cell proliferation factor and has been implicated in autoimmunity, tumorigenesis and transplantation tolerance. We have identified three single base pair substitutions in the IL-10 gene promoter and have investigated whether this polymorphism correlates with IL-10 protein production in vitro.
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