<i>mSlo</i> , a Complex Mouse Gene Encoding "Maxi" Calcium-Activated Potassium Channels
Alice Butler(Washington University in St. Louis), Susan Tsunoda(Washington University in St. Louis), David P. McCobb(Washington University in St. Louis), Aguan Wei(Washington University in St. Louis), Lawrence Salkoff(Washington University in St. Louis)
Cited by 648
Abstract
Complementary DNAs (cDNAs) from mSlo, a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo-encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.
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