Bone Cell Differentiation and Growth Factors
Marshall R. Urist(University of California, Los Angeles), Robert J. DeLange(University of California, Los Angeles), Gerald A. M. Finerman(University of California, Los Angeles)
Cited by 876
Abstract
Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.
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