Optical and MRI Multifunctional Nanoprobe for Targeting Gliomas
Omid Veiseh(University of Washington), Conroy Sun(University of Washington), Jonathan Gunn(University of Washington), Nathan Kohler(University of Washington), Patrik Gabikian(University of Washington), Donghoon Lee(University of Washington), Narayan Bhattarai(University of Washington), Richard G. Ellenbogen(University of Washington), Raymond W. Sze(University of Washington), Andrew R. Hallahan(University of Washington), Jim Olson(University of Washington), Miqin Zhang(University of Washington)
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Abstract
A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.
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