Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus

Kristina I. Rother(National Institute of Diabetes and Digestive and Kidney Diseases), David M. Harlan(National Institute of Diabetes and Digestive and Kidney Diseases)
Journal of Clinical Investigation
October 1, 2004
10.1172/jci23235
Cited by 187Open Access
Full Text

Abstract

Islet transplantation represents a most impressive recent advance in the search for a type 1 diabetes mellitus cure. While several hundred patients have achieved at least temporary insulin independence after receiving the islet "mini-organs" (containing insulin-producing beta cells), very few patients remain insulin independent beyond 4 years after transplantation. In this review, we describe historic as well as technical details about the procedure and provide insight into clinical and basic research efforts to overcome existing hurdles for this promising therapy.

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