Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Pawel Buczkowicz; Christine M. Hoeman; Patricia Rakopoulos; Sanja Pajovic; Louis Létourneau; Misko Dzamba; Andrew Morrison; Peter W. Lewis; Éric Bouffet; Ute Bartels; Jennifer Zuccaro; Sameer Agnihotri; Scott Ryall; Mark Barszczyk; Yevgen Chornenkyy; Mathieu Bourgey; Guillaume Bourque; Alexandre Montpetit; Francisco J. Cordero; Pedro Castelo‐Branco; Joshua Mangerel; Uri Tabori; King Ching Ho; Annie Huang; Kathryn R. Taylor; Alan Mackay; Anne Bendel; Javad Nazarian; Jason Fangusaro; Matthias A. Karajannis; David Zagzag; Nicholas K. Foreman; Andrew M. Donson; Julia Hegert; Amy Smith; Jennifer A. Chan; Lucy Lafay-Cousin; Sandra E. Dunn; Juliette Hukin; Christopher Dunham; Katrin Scheinemann; Jean Michaud; Shayna Zelcer; David A. Ramsay; Jason E. Cain; Cameron Brennan; Mark M. Souweidane; Chris Jones; C. David Allis; Michael Brudno; Oren J. Becher; Cynthia Hawkins

doi:10.1038/ng.2936

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Pawel Buczkowicz(University of Toronto), Christine M. Hoeman(Duke Medical Center), Patricia Rakopoulos(SickKids Foundation), Sanja Pajovic(Hospital for Sick Children), Louis Létourneau(McGill University and Génome Québec Innovation Centre), Misko Dzamba(University of Toronto), Andrew Morrison(Hospital for Sick Children), Peter W. Lewis(Rockefeller University), Éric Bouffet(Hospital for Sick Children), Ute Bartels(Hospital for Sick Children), Jennifer Zuccaro(Hospital for Sick Children), Sameer Agnihotri(Hospital for Sick Children), Scott Ryall(Hospital for Sick Children), Mark Barszczyk(SickKids Foundation), Yevgen Chornenkyy(University of Toronto), Mathieu Bourgey(McGill University and Génome Québec Innovation Centre), Guillaume Bourque(McGill University and Génome Québec Innovation Centre), Alexandre Montpetit(McGill University and Génome Québec Innovation Centre), Francisco J. Cordero(Duke Medical Center), Pedro Castelo‐Branco(SickKids Foundation), Joshua Mangerel(Hospital for Sick Children), Uri Tabori(SickKids Foundation), King Ching Ho(SickKids Foundation), Annie Huang(Hospital for Sick Children), Kathryn R. Taylor(Institute of Cancer Research), Alan Mackay(Institute of Cancer Research), Anne Bendel(Children's Minnesota), Javad Nazarian(Children's National), Jason Fangusaro(Lurie Children's Hospital), Matthias A. Karajannis(NYU Langone Health), David Zagzag(NYU Langone Health), Nicholas K. Foreman(Children's Hospital Colorado), Andrew M. Donson(University of Colorado Denver), Julia Hegert(Arnold Palmer Hospital for Children), Amy Smith(Arnold Palmer Hospital for Children), Jennifer A. Chan(University of Calgary), Lucy Lafay-Cousin(University of Calgary), Sandra E. Dunn(British Columbia Children's Hospital), Juliette Hukin(British Columbia Children's Hospital), Christopher Dunham(British Columbia Children's Hospital), Katrin Scheinemann(McMaster Children's Hospital), Jean Michaud(Children's Hospital of Eastern Ontario), Shayna Zelcer(London Health Sciences Centre), David A. Ramsay(London Health Sciences Centre), Jason E. Cain(Monash Medical Centre), Cameron Brennan(Cornell University), Mark M. Souweidane(Memorial Sloan Kettering Cancer Center), Chris Jones(Institute of Cancer Research), C. David Allis(Rockefeller University), Michael Brudno(Hospital for Sick Children), Oren J. Becher(Duke Medical Center), Cynthia Hawkins(University of Toronto)

Nature Genetics

April 6, 2014

10.1038/ng.2936

Cited by 653Open Access

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