TOPORS Functions As A SUMO-1 E3 Ligase for Chromatin-Modifying Proteins
Pooja Pungaliya(Rutgers, The State University of New Jersey), Diptee Kulkarni(Rutgers Cancer Institute of New Jersey), Hyejin Park(Rutgers Cancer Institute of New Jersey), Henderson Marshall(Rutgers, The State University of New Jersey), Haiyan Zheng(Rutgers, The State University of New Jersey), Henry Lackland(Rutgers, The State University of New Jersey), Ahamed Saleem(Rutgers, The State University of New Jersey), Eric H. Rubin(Rutgers, The State University of New Jersey)
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Abstract
TOPORS is the first example of a protein with both ubiquitin and SUMO-1 E3 ligase activity and has been implicated as a tumor suppressor in several different malignancies. To gain insight into the cellular role of TOPORS, a proteomic screen was performed to identify candidate sumoylation substrates. The results indicate that many of the putative substrates are involved in chromatin modification or transcriptional regulation. Transfection studies confirmed mammalian Sin3A as a sumoylation substrate for TOPORS. These findings suggest that TOPORS may function as a tumor suppressor by regulating mSin3A and other proteins involved in chromatin modification.
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