CD8 <sup>+</sup> Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication
Christopher M. Walker(Cancer Research Institute), Dewey J. Moody(University of California, San Francisco), Daniel P. Stites(University of California, San Francisco), Jay A. Levy(Cancer Research Institute)
Cited by 993
Abstract
Lymphocytes bearing the CD8 marker were shown to suppress replication of human immunodeficiency virus (HIV) in peripheral blood mononuclear cells. The effect was dose-dependent and most apparent with autologous lymphocytes; it did not appear to be mediated by a cytotoxic response. This suppression of HIV replication could be demonstrated by the addition of CD8+ cells at the initiation of virus production as well as after several weeks of virus replication by cultured cells. The observations suggest a potential approach to therapy in which autologous CD8 lymphocytes could be administered to individuals to inhibit HIV replication and perhaps progression of disease.