Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

BOCS; Kyriaki Michailidou; kConFab Investigators; AOCS Group; NBCS; GENICA Network; Jonathan Beesley; Sara Lindström; Sander Canisius; Joe Dennis; Michael Lush; Mel Maranian; Manjeet K. Bolla; Qin Wang; Mitul Shah; Barbara Perkins; Kamila Czene; Mikael Eriksson; Hatef Darabi; Judith S. Brand; Stig E. Bojesen; Børge G. Nordestgaard; Henrik Flyger; Sune F. Nielsen; Nazneen Rahman; Clare Turnbull; Olivia Fletcher; Julian Peto; Lorna J. Gibson; Isabel dos‐Santos‐Silva; Jenny Chang‐Claude; Dieter Flesch‐Janys; Anja Rudolph; Ursula Eilber; Sabine Behrens; Heli Nevanlinna; Taru Muranen; Kristiina Aittomäki; Carl Blomqvist; Sofia Khan; Kirsimari Aaltonen; Habibul Ahsan; Muhammad G. Kibriya; Alice S. Whittemore; Esther M. John; Kathleen E. Malone; Marilie D. Gammon; Regina M. Santella; Giske Ursin; Enes Makalic; Daniel F. Schmidt; Graham Casey; David J. Hunter; Susan M. Gapstur; Mia M. Gaudet; W. Ryan Diver; Christopher A. Haiman; Fredrick R. Schumacher; Brian E. Henderson; Loı̈c Le Marchand; Christine D. Berg; Stephen J. Chanock; Jonine D. Figueroa; Robert N. Hoover; Diether Lambrechts; Patrick Neven; Hans Wildiers; Erik Van Limbergen; Marjanka K. Schmidt; Annegien Broeks; Senno Verhoef; Sten Cornelissen; Fergus J. Couch; Janet E. Olson; Emily Hallberg; Celine M. Vachon; Quinten Waisfisz; Hanne Meijers‐Heijboer; Muriel A. Adank; Rob B. van der Luijt; Jingmei Li; Jianjun Liu; Keith Humphreys; Daehee Kang; Ji‐Yeob Choi; Sue K. Park; Keun-Young Yoo; Keitaro Matsuo; Hidemi Ito; Hiroji Iwata; Kazuo Tajima; Pascal Guénel; Thérèse Truong; Claire Mulot; Marie Sanchez; Barbara Burwinkel; Frederik Marmé; Harald Surowy; Christof Sohn; Anna H. Wu; Chiu-Chen Tseng; David Van Den Berg; Daniel O. Stram; Anna González‐Neira; Javier Benı́tez; M. Pilar Zamora; José Ignacio Arias Pérez; Xiao‐Ou Shu; Wei Lu; Yu‐Tang Gao; Hui Cai; Angela Cox; Simon S. Cross; Malcolm Reed; Irene L. Andrulis; Julia A. Knight; Gord Glendon; Anna Marie Mulligan; Elinor J. Sawyer; Ian Tomlinson; Michael J. Kerin; Nicola Miller; Annika Lindblom; Sara Margolin; Soo‐Hwang Teo; Cheng Har Yip; Nur Aishah Mohd Taib; Gie-Hooi Tan; Maartje J. Hooning; Antoinette Hollestelle; John W.M. Martens; J. Margriet Collée; William J. Blot; Lisa B. Signorello; Qiuyin Cai; John L. Hopper; Melissa C. Southey; Helen Tsimiklis; Carmel Apicella; Chen‐Yang Shen; Chia‐Ni Hsiung; Pei‐Ei Wu; Ming‐Feng Hou; Vessela N. Kristensen; Silje Nord; Grethe I.G. Alnæs; Graham G. Giles; Roger L. Milne; Catriona McLean; Federico Canzian; Dimitrios Trichopoulos; Petra H. Peeters; Eiliv Lund; Malin Sund; Kay‐Tee Khaw; Marc J. Gunter; Domenico Palli; Lotte Maxild Mortensen; Laure Dossus; José María Huerta; Alfons Meindl; Rita K. Schmutzler; Christian Sutter; Rongxi Yang; Kenneth Muir; Artitaya Lophatananon; Sarah Stewart‐Brown; Pornthep Siriwanarangsan; Mikael Hartman; Hui Miao; Kee Seng Chia; Ching Wan Chan; Peter A. Fasching; Alexander Hein; Matthias W. Beckmann; Lothar Haeberle; Hermann Brenner; Aida Karina Dieffenbach; Volker Arndt; Christa Stegmaier; Alan Ashworth; Nick Orr; Minouk J. Schoemaker; Anthony J. Swerdlow; Louise A. Brinton; Montserrat García‐Closas; Wei Zheng; Sandra L. Halverson; Martha J. Shrubsole; Jirong Long; Mark S. Goldberg; France Labrèche; Martine Dumont; Robert Winqvist; Katri Pylkäs; Arja Jukkola‐Vuorinen; Mervi Grip; Hiltrud Brauch; Ute Hamann; Thomas Brüning; Paolo Radice; Paolo Peterlongo; Siranoush Manoukian; Loris Bernard; Natalia Bogdanova; Thilo Dörk; Arto Mannermaa; Vesa Kataja; Veli‐Matti Kosma; Jaana M. Hartikainen; Peter Devilee; Robert A.E.M. Tollenaar; Caroline Seynaeve; Christi J. van Asperen; Anna Jakubowska; Jan Lubiński; Katarzyna Jaworska; Tomasz Huzarski; Suleeporn Sangrajrang; Valérie Gaborieau; Paul Brennan; James McKay; Susan Slager; Amanda E. Toland; Christine B. Ambrosone; Drakoulis Yannoukakos; Maria Kabisch; Diana Torres; Susan L. Neuhausen; Hoda Anton‐Culver; Craig Luccarini; Caroline Baynes; Shahana Ahmed; Catherine S. Healey; Daniel C. Tessier; Daniel Vincent; François Bacot; Guillermo Pita; M. Rosario Alonso; Núria Álvarez; Daniel Herrero; Jacques Simard; Paul D.P. Pharoah; Peter Kraft; Alison M. Dunning; Georgia Chenevix‐Trench; Per Hall; Douglas F. Easton

doi:10.1038/ng.3242

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

BOCS(University of Cambridge), Kyriaki Michailidou(QIMR Berghofer Medical Research Institute), kConFab Investigators(Harvard University), AOCS Group(The Netherlands Cancer Institute), NBCS(University of Cambridge), GENICA Network(University of Cambridge), Jonathan Beesley(QIMR Berghofer Medical Research Institute), Sara Lindström(Harvard University), Sander Canisius(University of Cambridge), Joe Dennis(University of Cambridge), Michael Lush(University of Cambridge), Mel Maranian(University of Cambridge), Manjeet K. Bolla(University of Cambridge), Qin Wang(University of Cambridge), Mitul Shah(University of Cambridge), Barbara Perkins(University of Cambridge), Kamila Czene(Herlev Hospital), Mikael Eriksson(Herlev Hospital), Hatef Darabi(Herlev Hospital), Judith S. Brand(Institute of Cancer Research), Stig E. Bojesen(Institute of Cancer Research), Børge G. Nordestgaard(Institute of Cancer Research), Henrik Flyger(Herlev Hospital), Sune F. Nielsen(Herlev Hospital), Nazneen Rahman(Institute of Cancer Research), Clare Turnbull(Institute of Cancer Research), Olivia Fletcher(Institute of Cancer Research), Julian Peto(German Cancer Research Center), Lorna J. Gibson(German Cancer Research Center), Isabel dos‐Santos‐Silva(German Cancer Research Center), Jenny Chang‐Claude(University of Helsinki), Dieter Flesch‐Janys(University of Helsinki), Anja Rudolph(German Cancer Research Center), Ursula Eilber(University of Helsinki), Sabine Behrens(University of Helsinki), Heli Nevanlinna(University of Helsinki), Taru Muranen(University of Helsinki), Kristiina Aittomäki(Chicago Department of Public Health), Carl Blomqvist(University of Helsinki), Sofia Khan(Cancer Prevention Institute of California), Kirsimari Aaltonen(University of Helsinki), Habibul Ahsan(University of North Carolina at Chapel Hill), Muhammad G. Kibriya(Chicago Department of Public Health), Alice S. Whittemore(Cancer Registry of Norway), Esther M. John(Cancer Prevention Institute of California), Kathleen E. Malone(Fred Hutch Cancer Center), Marilie D. Gammon(University of North Carolina at Chapel Hill), Regina M. Santella(Harvard University), Giske Ursin(American Cancer Society), Enes Makalic(American Cancer Society), Daniel F. Schmidt(American Cancer Society), Graham Casey(University of Southern California), David J. Hunter(University of Southern California), Susan M. Gapstur(University of Southern California), Mia M. Gaudet(University of Hawaiʻi at Mānoa), W. Ryan Diver(American Cancer Society), Christopher A. Haiman(University of Southern California), Fredrick R. Schumacher(University of Southern California), Brian E. Henderson(University of Southern California), Loı̈c Le Marchand(University of Hawaiʻi at Mānoa), Christine D. Berg(Johns Hopkins University), Stephen J. Chanock(National Cancer Institute), Jonine D. Figueroa(National Cancer Institute), Robert N. Hoover(The Netherlands Cancer Institute), Diether Lambrechts(The Netherlands Cancer Institute), Patrick Neven(The Netherlands Cancer Institute), Hans Wildiers(The Netherlands Cancer Institute), Erik Van Limbergen(Mayo Clinic), Marjanka K. Schmidt(The Netherlands Cancer Institute), Annegien Broeks(The Netherlands Cancer Institute), Senno Verhoef(The Netherlands Cancer Institute), Sten Cornelissen(The Netherlands Cancer Institute), Fergus J. Couch(Mayo Clinic), Janet E. Olson(Mayo Clinic in Florida), Emily Hallberg(University Medical Center Utrecht), Celine M. Vachon(Karolinska Institutet), Quinten Waisfisz(Genome Institute of Singapore), Hanne Meijers‐Heijboer(Karolinska Institutet), Muriel A. Adank(Seoul National University), Rob B. van der Luijt(Cancer Research Institute), Jingmei Li(Seoul National University), Jianjun Liu(Seoul National University), Keith Humphreys(Kyushu University), Daehee Kang(Seoul National University), Ji‐Yeob Choi(Cancer Research Institute), Sue K. Park(Seoul National University), Keun-Young Yoo(Seoul National University), Keitaro Matsuo(Kyushu University), Hidemi Ito(Inserm), Hiroji Iwata(Inserm), Kazuo Tajima(German Cancer Research Center), Pascal Guénel(Inserm), Thérèse Truong(Inserm), Claire Mulot(Inserm), Marie Sanchez(University of Southern California), Barbara Burwinkel(University of Southern California), Frederik Marmé(University of Southern California), Harald Surowy(University of Southern California), Christof Sohn(Heidelberg University), Anna H. Wu(University of Southern California), Chiu-Chen Tseng(University of Southern California), David Van Den Berg(University of Southern California), Daniel O. Stram(University of Southern California), Anna González‐Neira(Spanish National Cancer Research Centre), Javier Benı́tez(Spanish National Cancer Research Centre), M. Pilar Zamora(Vanderbilt University), José Ignacio Arias Pérez(Hospital Monte Naranco), Xiao‐Ou Shu(Vanderbilt University), Wei Lu(Shanghai Municipal Center For Disease Control Prevention), Yu‐Tang Gao(Lunenfeld-Tanenbaum Research Institute), Hui Cai(Vanderbilt University), Angela Cox(Mount Sinai Hospital), Simon S. Cross(University Health Network), Malcolm Reed(Guy's Hospital), Irene L. Andrulis(Centre for Human Genetics), Julia A. Knight(Ollscoil na Gaillimhe – University of Galway), Gord Glendon(Mount Sinai Hospital), Anna Marie Mulligan(University Health Network), Elinor J. Sawyer(Guy's Hospital), Ian Tomlinson(University Malaya Medical Centre), Michael J. Kerin(University Malaya Medical Centre), Nicola Miller(University Malaya Medical Centre), Annika Lindblom(University Malaya Medical Centre), Sara Margolin(Karolinska Institutet), Soo‐Hwang Teo(University Malaya Medical Centre), Cheng Har Yip(University Malaya Medical Centre), Nur Aishah Mohd Taib(University Malaya Medical Centre), Gie-Hooi Tan(University Malaya Medical Centre), Maartje J. Hooning(Harvard University), Antoinette Hollestelle(Vanderbilt University), John W.M. Martens(The University of Melbourne), J. Margriet Collée(The University of Melbourne), William J. Blot(The University of Melbourne), Lisa B. Signorello(Harvard University), Qiuyin Cai(China Medical University), John L. Hopper(The University of Melbourne), Melissa C. Southey(The University of Melbourne), Helen Tsimiklis(The University of Melbourne), Carmel Apicella(Oslo University Hospital), Chen‐Yang Shen(Oslo University Hospital), Chia‐Ni Hsiung(Oslo University Hospital), Pei‐Ei Wu(Cancer Council Victoria), Ming‐Feng Hou(Cancer Council Victoria), Vessela N. Kristensen(Oslo University Hospital), Silje Nord(Oslo University Hospital), Grethe I.G. Alnæs(Oslo University Hospital), Graham G. Giles(Cancer Council Victoria), Roger L. Milne(Cancer Council Victoria), Catriona McLean(The Alfred Hospital), Federico Canzian(German Cancer Research Center), Dimitrios Trichopoulos(Hellenic Health Foundation), Petra H. Peeters(University Medical Center Utrecht), Eiliv Lund(Aarhus University), Malin Sund(Université Paris-Sud), Kay‐Tee Khaw(University of Cambridge), Marc J. Gunter(Imperial College London), Domenico Palli(Istituto per lo Studio e la Prevenzione Oncologica), Lotte Maxild Mortensen(Aarhus University), Laure Dossus(Université Paris-Sud), José María Huerta(University of Warwick), Alfons Meindl(University of Warwick), Rita K. Schmutzler(University of Warwick), Christian Sutter(Ministry of Public Health), Rongxi Yang(German Cancer Research Center), Kenneth Muir(National University of Singapore), Artitaya Lophatananon(National University of Singapore), Sarah Stewart‐Brown(University of Warwick), Pornthep Siriwanarangsan(Ministry of Public Health), Mikael Hartman(Universitätsklinikum Erlangen), Hui Miao(National University of Singapore), Kee Seng Chia(National University of Singapore), Ching Wan Chan(German Cancer Research Center), Peter A. Fasching(German Cancer Research Center), Alexander Hein(German Cancer Research Center), Matthias W. Beckmann(Universitätsklinikum Erlangen), Lothar Haeberle(Institute of Cancer Research), Hermann Brenner(Institute of Cancer Research), Aida Karina Dieffenbach(Institute of Cancer Research), Volker Arndt(Institute of Cancer Research), Christa Stegmaier(National Cancer Institute), Alan Ashworth(Institute of Cancer Research), Nick Orr(Institute of Cancer Research), Minouk J. Schoemaker(Institute of Cancer Research), Anthony J. Swerdlow(Institute of Cancer Research), Louise A. Brinton(Vanderbilt University), Montserrat García‐Closas(Breast Cancer Now), Wei Zheng(Vanderbilt University), Sandra L. Halverson(Vanderbilt University), Martha J. Shrubsole(Vanderbilt University), Jirong Long(Vanderbilt University), Mark S. Goldberg(Oulu University Hospital), France Labrèche(Oulu University Hospital), Martine Dumont(German Cancer Research Center), Robert Winqvist(German Cancer Research Center), Katri Pylkäs(Oulu University Hospital), Arja Jukkola‐Vuorinen(Oulu University Hospital), Mervi Grip(Oulu University Hospital), Hiltrud Brauch(German Cancer Research Center), Ute Hamann(German Cancer Research Center), Thomas Brüning(Medizinische Hochschule Hannover), Paolo Radice(Medizinische Hochschule Hannover), Paolo Peterlongo(University of Eastern Finland), Siranoush Manoukian(Central Finland Health Care District), Loris Bernard(University of Eastern Finland), Natalia Bogdanova(University of Eastern Finland), Thilo Dörk(Leiden University Medical Center), Arto Mannermaa(University of Eastern Finland), Vesa Kataja(Central Finland Health Care District), Veli‐Matti Kosma(University of Eastern Finland), Jaana M. Hartikainen(University of Eastern Finland), Peter Devilee(Leiden University Medical Center), Robert A.E.M. Tollenaar(Leiden University Medical Center), Caroline Seynaeve(Erasmus MC Cancer Institute), Christi J. van Asperen(Leiden University Medical Center), Anna Jakubowska(Centre international de recherche sur le cancer), Jan Lubiński(Centre international de recherche sur le cancer), Katarzyna Jaworska(Centre international de recherche sur le cancer), Tomasz Huzarski(Mayo Clinic in Florida), Suleeporn Sangrajrang(National Cancer Institute of Thailand), Valérie Gaborieau(Roswell Park Comprehensive Cancer Center), Paul Brennan(National Centre of Scientific Research "Demokritos"), James McKay(German Cancer Research Center), Susan Slager(German Cancer Research Center), Amanda E. Toland(City of Hope), Christine B. Ambrosone(Roswell Park Comprehensive Cancer Center), Drakoulis Yannoukakos(National Centre of Scientific Research "Demokritos"), Maria Kabisch(German Cancer Research Center), Diana Torres(German Cancer Research Center), Susan L. Neuhausen(University of Cambridge), Hoda Anton‐Culver(University of California, Irvine), Craig Luccarini(University of Cambridge), Caroline Baynes(University of Cambridge), Shahana Ahmed(University of Cambridge), Catherine S. Healey(University of Cambridge), Daniel C. Tessier(Spanish National Cancer Research Centre), Daniel Vincent(Spanish National Cancer Research Centre), François Bacot(Centre hospitalier universitaire de Québec), Guillermo Pita(Cancer Research UK), M. Rosario Alonso(Harvard University), Núria Álvarez(University of Cambridge), Daniel Herrero(QIMR Berghofer Medical Research Institute), Jacques Simard(Karolinska Institutet), Paul D.P. Pharoah(Cancer Research UK), Peter Kraft(Harvard University), Alison M. Dunning(University of Cambridge), Georgia Chenevix‐Trench(QIMR Berghofer Medical Research Institute), Per Hall(Karolinska Institutet), Douglas F. Easton(Cancer Research UK)

Nature Genetics

March 9, 2015

10.1038/ng.3242

Cited by 632Open Access

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