Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell Lines
Andrea L. Cox(University of Virginia), Jonathan Skipper(Carter Center), Ye Chen(Carter Center), Robert Henderson(Carter Center), Timothy L. Darrow(Duke University), Jeffrey Shabanowitz(University of Virginia), Víctor H. Engelhard(Carter Center), Donald F. Hunt(University of Virginia), Craig L. Slingluff(University of Virginia)
Cited by 833
Abstract
Of several thousand peptides presented by the major histocompatibility molecule HLA-A2.1, at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem mass spectrometry was used to identify and to sequence one of these peptide epitopes. Melanoma-specific CTLs had an exceptionally high affinity for this nine-residue peptide, which reconstituted an epitope for CTL lines from each of five different melanoma patients tested. Recognition by multiple CTL lines suggests that this may be a promising candidate for use in peptide-based melanoma vaccines.
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