Genetic Risk Factors for Arterial Ischemic Stroke in Children: A Possible <i>MTHFR</i> and <i>eNOS</i> Gene-Gene Interplay?

Valentina Djordjević(Institute of Molecular Genetics and Genetic Engineering), Marija Stanković(Institute of Molecular Genetics and Genetic Engineering), Vesna Branković-Srećković, Ljiljana Rakićević(Institute of Molecular Genetics and Genetic Engineering), Dragica Radojković(Institute of Molecular Genetics and Genetic Engineering)
Journal of Child Neurology
April 15, 2009
10.1177/0883073808330164
Cited by 22

Abstract

In order to investigate the influence of genetic factors in childhood stroke, we compared the distributions of mutations/ polymorphisms affecting hemostasis and/or endothelial function (factor V [FV] Leiden, factor II [FII] G20210A, methylenetetrahydrofolate reductase [MTHFR] C677T, angiotensin-converting enzyme [ACE] insertion/deletion [ID], and endothelial nitric oxide synthase [eNOS] G894T) among children with stroke and controls. A total number of 26 children with arterial ischemic stroke and a control group of 50 healthy children were included in the study. No statistically significant differences in allelic and genotypic distribution were detected in comparisons between groups. However, when combined genotypes were analyzed, statistical significance was observed for the association of MTHFR CT and eNOS TT gene variants. The results of our study suggest that this genotype combination represents a risk factor of 7.2 (P = .017) for arterial ischemic stroke in children.

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