Leukotriene B <sub>4</sub> Produces Hyperalgesia That Is Dependent on Polymorphonuclear Leukocytes
Jon D. Levine(University of California, San Francisco), Wai Kit Lau(University of California, San Francisco), Geoffrey C. Kwiat(University of California, San Francisco), Edward J. Goetzl(Howard Hughes Medical Institute)
Cited by 292
Abstract
Leukotriene B4, at the same intracutaneous doses as bradykinin, reduced the nociceptive threshold in the rat paw. The mechanism of leukotriene B4-induced hyperalgesia was distinguished from that of the hyperalgesia elicited by prostaglandin E2 and bradykinin by its dependence on polymorphonuclear leukocytes and independence of the cyclooxygenation of arachidonic acid.
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