Anabolic Resistance of Muscle Protein Synthesis with Aging

Abstract

In Brief Aging has been associated with a reduced muscle protein synthetic response to protein intake, termed “anabolic resistance.” Physical activity performed before protein intake increases the use of protein-derived amino acids for postprandial muscle protein accretion in senescent muscle. Thus, the level of habitual physical activity may be fundamental to maintain the anabolic responsiveness to protein intake with aging. We provide evidence to suggest that maintenance of physical activity can reduce the anabolic resistance of muscle protein synthesis to protein intake with aging.