Lateral Transport of a Lipid Probe and Labeled Proteins on a Cell Membrane
Joseph Schlessinger(Cornell University), Daniel Axelrod(Cornell University), D E Koppel(Cornell University), W. W. Webb(Cornell University), E L Elson(Cornell University)
Cited by 252
Abstract
Diffusion coefficients (D) of a lipid probe and labeled proteins on L-6 myoblast membranes have been measured giving D(protein) approximately 2 X 10(-10) square centimeter per second and D (lipid probe) approximately 9 X 10(-9) square centimeter per second. Some of the membrane proteins are immobile, but the lipid probe diffuses freely over macroscopic distances. Cytochalasin B slows protein but not lipid probe diffusion.
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