A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A
Riki Kawaguchi(University of California, Los Angeles), Jiamei Yu(University of California, Los Angeles), Jane Honda(University of California, Los Angeles), Jane Hu(University of California, Los Angeles), Julian P. Whitelegge(University of California, Los Angeles), Peipei Ping(University of California, Los Angeles), Patrick Wiita(University of California, Los Angeles), Dean Bok(University of California, Los Angeles), Hui Sun(University of California, Los Angeles)
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Abstract
Vitamin A has diverse biological functions. It is transported in the blood as a complex with retinol binding protein (RBP), but the molecular mechanism by which vitamin A is absorbed by cells from the vitamin A-RBP complex is not clearly understood. We identified in bovine retinal pigment epithelium cells STRA6, a multitransmembrane domain protein, as a specific membrane receptor for RBP. STRA6 binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex. It is widely expressed in embryonic development and in adult organ systems. The RBP receptor represents a major physiological mediator of cellular vitamin A uptake.
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