Expression of HLA Class II Molecules in Humanized NOD.Rag1KO.IL2RgcKO Mice Is Critical for Development and Function of Human T and B Cells
Rebecca Danner(Walter Reed Army Institute of Research), Snehal N. Chaudhari(Naval Medical Research Command), J. K. Rosenberger(Naval Medical Research Command), Jacqueline Surls(Uniformed Services University of the Health Sciences), Thomas L. Richie(Walter Reed Army Institute of Research), Teodor-Doru Brumeanu(Uniformed Services University of the Health Sciences), Sofía Casares(Walter Reed Army Institute of Research)
Cited by 203Open Access
Abstract
Background: Humanized mice able to reconstitute a surrogate human immune system (HIS) can be used for studies on human immunology and may provide a predictive preclinical model for human vaccines prior to clinical trials. However, current humanized mouse models show sub-optimal human T cell reconstitution and limited ability to support immunoglobulin class switching by human B cells. This limitation has been attributed to the lack of expression of Human Leukocyte Antigens (HLA) molecules in mouse lymphoid organs. Recently, humanized mice expressing HLA class I molecules have been generated but showed little improvement in human T cell reconstitution and function of T and B cells.
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