Myeloma Proteins as Tumor-Specific Transplantation Antigens
Richard G. Lynch(Washington University in St. Louis), Ralph J. Graff(Washington University in St. Louis), Stitaya Sirisinha(Washington University in St. Louis), Ernest S. Simms(Washington University in St. Louis), Herman N. Eisen(Washington University in St. Louis)
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Abstract
BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the anti-idiotypic immune response selects against those myeloma cells that form the intact myeloma protein.
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