Cell Growth Inhibitory Effect of Cinnamic Acid Derivatives from Propolis on Human Tumor Cell Lines
Yukihiro Akao(Czech Academy of Sciences, Institute of Biotechnology), Hiroe Maruyama, Kenji Matsumoto(Czech Academy of Sciences, Institute of Biotechnology), Kenji Ohguchi(National Institute of Biotechnology), Kumi Nishizawa(National Institute of Biotechnology), Takashi Sakamoto, Yoko Araki, Satoshi Mishima, Yoshinori Nozawa(Czech Academy of Sciences, Institute of Biotechnology)
Cited by 171Open Access
Abstract
A cell growth inhibitory effect of drupanin and baccharin, ingredients of propolis, was found in human cancer cell lines. These compounds induced apoptosis in the cells characterized by morphological and nucleosomal DNA fragmentation analysis. Their effects were less potent compared with that of artepillin C, which is a known anticancer compound from propolis. Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin.
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