Control of Homeostasis of CD8 <sup>+</sup> Memory T Cells by Opposing Cytokines
Chia‐Chi Ku(Howard Hughes Medical Institute), Masaaki Murakami(Howard Hughes Medical Institute), Akemi Sakamoto(Howard Hughes Medical Institute), John W. Kappler(Howard Hughes Medical Institute), Philippa Marrack(Howard Hughes Medical Institute)
Cited by 817
Abstract
Memory T cells maintain their numbers for long periods after antigen exposure. Here we show that CD8+ T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2). Therefore, the numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2.
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